| 產(chǎn)品編號 | bs-2686R |
| 英文名稱 | DKK3 Rabbit pAb |
| 中文名稱 | 抑癌蛋白DKK3抗體 |
| 別 名 | Dickkopf 3; Dickkopf homolog 3; Dickkopf related protein 3; Dickkopf related protein 3 Precursor; Dickkopf3; DKK 3; DKK3; hDkk 3; hDkk3; REIC; RIG-like 5-6; RIG-like 7-1; DKK3_HUMAN; Dickkopf 3 homolog(Xenopus laevis); Dickkopf homolog 3; Dickkopf-3; Dickkopf-related protein 3; Dkk-3; hDkk-3; Regulated in glioma; RIG. |
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Specific References (2) | bs-2686R has been referenced in 2 publications.
[IF=1.922] Cao et al. Dickkopf?3 upregulation mediates the cardioprotective effects of curcumin on chronic heart failure. (2018) Mol.Med.Rep. 17:7249-7257 WB ; rabbit.
[IF=0.88] Ning, Shujie, et al. "Effect of autonomic nerves on Dickkopf-3 expression in the uterus during early pregnancy of rats."Animal Biology(2015). IHC-P ; Rat.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Pig,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 36 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DKK3: 31-130/350 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Dickkopf 3, like DKK1, DKK2, and DKK4, possesses an N terminal signal peptide and 2 conserved cysteine rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin type proteases. Subunit: Interacts with LRP5 and LRP6. Subcellular Location: Secreted. Tissue Specificity: Highest expression in heart, brain, and spinal cord. Similarity: Belongs to the dickkopf family. SWISS: Q9UBP4 Gene ID: 27122 Database links: Entrez Gene: 27122 Human NCBI: 40548393 Human Omim: 605416 Human SwissProt: Q9UBP4 Human Unigene: 292156 Human |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DKK3) Polyclonal Antibody, Unconjugated (bs-2686R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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