| 產(chǎn)品編號 | bs-18456R |
| 英文名稱 | LYAR Rabbit pAb |
| 中文名稱 | 細(xì)胞生長調(diào)節(jié)核仁蛋白抗體 |
| 別 名 | Cell growth regulating nucleolar protein; Cell growth-regulating nucleolar protein; Likely ortholog of mouse Ly1; reactive clone; Ly1; reactive; Ly1; reactive homolog(mouse); Ly1; reactive homolog; LYAR; LYAR_HUMAN; ZC2HC2; ZLYAR. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 44 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LYAR: 1-100/379 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
LYAR is a 379 amino acid nucleolar protein containing two C2HC-type zinc fingers. Expressed at high levels in immature spermatocytes, early embryos and in fetal liver and thymus with low expression in kidney and spleen, LYAR may function as a novel nucleolar oncoprotein to regulate cell growth. It is suggested that LYAR participates in regulating the stability of C23, a protein that is critical for maintaining the self-renewal and differentiation of embryonic stem cells (ESCs). C23 is a eukaryotic nucleolar phosphoprotein that influences synthesis and maturation of ribosomes. LYAR forms a complex with C23, thereby preventing self-cleavage and maintaining steady levels of C23 in undifferentiated ESCs. Downregulation of LYAR decreases C23 stability in ESCs, which in turn negatively affects growth and increases the rate of apoptosis of these cells. Subcellular Location: Nucleus Similarity: Contains 2 C2HC-type zinc fingers. SWISS: Q9NX58 Gene ID: 55646 Database links: Entrez Gene: 55646 Human Entrez Gene: 17089 Mouse SwissProt: Q9NX58 Human SwissProt: Q08288 Mouse Unigene: 425427 Human Unigene: 28560 Mouse Unigene: 137862 Rat |
