| 產(chǎn)品編號(hào) |
bsk11157 |
| 英文名稱 |
Human IGFBP-7/IGFBP-rp1 ELISA Kit
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| 中文名稱 |
人胰島素樣生長(zhǎng)因子結(jié)合蛋白-7酶聯(lián)免疫試劑盒 |
| 別 名 |
AGM; Angiomodulin; FSTL2; IBP-7; IBP7; IBP7_HUMAN; IGF binding protein 7; IGF-binding protein 7; IGFBP rP1; IGFBP-7; IGFBP-rP1; IGFBP7; IGFBPRP1; Insulin like growth factor binding protein 7; Insulin-like growth factor-binding protein 7; MAC25; MAC25 prot |
| 種 屬 |
Human |
| 線性范圍 |
78 - 5000 pg/mL |
| 應(yīng)用范圍 |
S/P/CC |
| 檢測(cè)限 |
39 pg/mL |
| 適用樣品基質(zhì) |
cell culture supernates, serum, and plasma. |
| 保存條件 |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.). |
| 注意事項(xiàng) |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
IGF-BPs form high affinity complexes with both IGF-I and IGF-II and act to control of the distribution, function and activity of IGFs in various cell tissues and body fluids. There are seven named IGF-BPs. IGFBP7 plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. IGFBP7 is expressed in a wide range of normal human tissues and it usually shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin.
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