| 產(chǎn)品編號(hào) | bs-2500R-BF350 |
| 英文名稱 | Rabbit Anti-IRF4/BF350 Conjugated antibody |
| 中文名稱 | BF350標(biāo)記的干擾素調(diào)節(jié)因子4抗體 |
| 別 名 | Interferon regulatory factor 4; IRF 4; IRF4; IRF-4; LSIRF; Lymphocyte specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM 1; NF EM5; NFEM5; OTTHUMP00000017905; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; Transcriptional activator PIP; IRF4_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IRF-4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010] Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). Subunit: Interacts with the BATF-JUNB heterodimer. Interacts with BATF (via bZIP domain); the interaction is direct. Interacts with SPIB and DEF6. Subcellular Location: Nucleus. Tissue Specificity: Lymphoid cells. Post-translational modifications: Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. DISEASE: Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving IRF4 has been found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus. Similarity: Belongs to the IRF family. Contains 1 IRF tryptophan pentad repeat DNA-binding domain. Database links: Entrez Gene: 374179 Chicken Entrez Gene: 3662 Human Entrez Gene: 16364 Mouse Omim: 601900 Human SwissProt: Q15306 Human SwissProt: Q64287 Mouse Unigene: 401013 Human Unigene: 4677 Mouse Unigene: 82114 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 轉(zhuǎn)錄調(diào)節(jié)因子（Transcriptin Regulators） 干擾素調(diào)節(jié)因子家族是一大類對(duì)干擾素起調(diào)控作用的轉(zhuǎn)錄因子的統(tǒng)稱。一般認(rèn)為干擾素調(diào)節(jié)因子(IRF)通過(guò)調(diào)節(jié)干擾素的表達(dá)而行使其抗病毒、應(yīng)激、免疫調(diào)節(jié)功能。近年來(lái)，研究人員發(fā)現(xiàn)IRF在細(xì)胞凋亡、細(xì)胞周期、細(xì)胞分化、腫瘤發(fā)生中也起著重要的調(diào)節(jié)作用。 |
